The US and Israel launched airstrikes against Iran Saturday morning, with the initial attack near Supreme Leader Ayatollah Ali Khamenei’s Tehran office.

The airstrikes are a response to the regime’s refusal to dismantle its nuclear program following weeks of talks — and as the US increased its military presence in the Middle East after President Trump warned Tehran there would be consequences if a deal was not reached. Israel later confirmed that the joint strikes targeted the Supreme Leader and Iran’s President Masoud Pezeshkian.

“It’s a very simple message. They will never have a nuclear weapon,” Trump vowed in a video message posted on Truth Social just before 3 a.m.

He warned Tehran to “lay down your arms or face certain death.”

Iran later warned that the “first wave of extensive missile and drone attacks” is underway across Israel.